Projects & Scientific Cores

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Research Projects

Our Center supports three research projects that are highly complementary and synergistic. The design of these projects exploits several existing cross-institutional collaborations, strategic academic-industry partnerships and many complementary research strengths. Here we briefly describe each research project with an emphasis on the major goals, experimental approaches and interactions with other projects and cores.

Project 1: High Throughput Functional Evaluation of Ion Channel Variants in Epilepsy

Project 2: Investigation of human neuron models of channelopathy-associated epilepsy

Project 3: Development and investigation of murine models of channelopathy-associated epilepsy

Scientific Cores

Our Center proposes two scientific cores that will serve all of the research projects directly or indirectly.

Core A: Variant Prioritization and Curation

Core B: Mutagenesis and Cell Expression